By Basant El-Faramawy
A wireless electronic implant that removes excess glucose directly from the bloodstream could offer a drug-free way to manage type 2 diabetes and obesity, according to a landmark study published in the journal Science.
Device clears glucose without drugs or insulin
Developed by bioengineers at ETH Zurich, the under-the-skin implant uses an electrically powered catalyst to break down excess blood sugar. In trials on mice with both conditions, elevated glucose levels returned to normal within 60 to 90 minutes of activation. Over six weeks, the animals lost up to 10 per cent of their body weight and showed significant reductions in triglycerides.
Catalyst converts glucose into excretable compound
The implant contains a catalyst made of gold flakes and platinum particles layered onto spongelike graphite. When powered by low-voltage electricity, it converts glucose into gluconate, a compound the kidneys can easily flush out in urine. Unlike conventional treatments such as insulin injections or GLP-1 receptor agonists like Ozempic and Mounjaro, the system requires no added drugs, genes, or living cells.
Automatic monitoring via smartphone
The device functions as a continuous glucose monitor. It detects elevated blood sugar and relays readings through a smartphone that wirelessly switches the implant on. When levels drop to a safe range, the device shuts off automatically.
Experts urge caution before human trials
Independent experts warn that major hurdles remain. Dr David Klonoff, an endocrinologist at Sutter Mills-Peninsula Medical Center, said the method is potentially promising but carries significant risks. He highlighted the need to establish how much gluconate human kidneys can process, as accumulation could disrupt acid-base balance and deplete essential electrolytes.
Next steps: larger animal studies
Professor Martin Fussenegger's team plans to test the system in larger animals, including pigs and sheep, before moving toward human clinical trials. If proven safe and effective, the implant could provide an alternative to traditional diabetes therapies and open a new route for weight management regardless of diabetes status.
