By Fatma Younis
Scientists have discovered a link between cold temperatures and increased lifespan, identifying a muscle-derived molecule called BH2 as a key mediator of the anti-ageing effects.
Muscle tissue and BH2 play central role
Researchers at the University of Cologne found that moderately cold temperatures boost production of dihydrobiopterin (BH2) in muscle tissue. This molecule then travels to other parts of the body, helping maintain protein homeostasis and protecting against age-related protein misfolding.
Potential for treating Huntington’s and ALS
Tests in human cell models of Huntington’s disease and amyotrophic lateral sclerosis (ALS) showed that BH2 and the amino acid tyrosine could reproduce some protective effects of cold exposure. Lead author David Vilchez said targeting muscle could provide organism-wide protection, though a therapeutic “pill” remains at an early stage.
Further research needed
The study, published in Nature, used the nematode Caenorhabditis elegans and human cells. Scientists caution that more work is required to develop treatments that mimic cold benefits without lowering body temperature.
